Makorin is a marker for stem cells: Brahma (Creator)
Makorin plays a role in embryogenesis and early development: Vishnu (Preserver)
Makorin acts as E3 Ligase during ubiquitination: Shiva (destroyer)
Reference
1.Gray, T. A., A. H. Hernandez, L. H. Carey, M. A. Schaldach, M. J. Smithwick, K. Rus, J. A. M. Graves, C. L. Stewart and R. D. Nicholls. 2000. Genomics 66:76–86.
2.Lee E.W, M.S. Lee, S. Camus, J. Ghim, M. Yang, W. Oh, N. Ha, D. P. Lane and J. Song. 2009. The EMBO Journal. 28: 2100–2113.
3.http://www.wipo.int/pctdb/en/wo.jsp?WO=2008055361&IA=CA2007002034&DISPLAY=STATUS
Monday, November 22, 2010
Wednesday, September 8, 2010
EMBO 2010 and Scientific Networking
Conferences and meetings arranged by various scientific organizations provide a platform for science, career development, business, and policy making to come together. They help give a good exposure to scientists about the latest developments in research. Apart from science they are good chance to visit new places and learn about new cultures.
Fifteen thousand letters, that’s the number of letters which the Darwin Correspondence Project claims to have archived. These are letters which Darwin and his contemporary biologists exchanged. What was the purpose? The answer is NETWORKING. Darwin would have faired well in twittering or facebooking.
Well in the present day world, it has become much more easier for scientists to come and meet at platforms like the EMBO meetings etc. What else do you need when you have Nobel laureates, an author of a best seller, top scientists, editors of high profile journals, top business companies of science and the young minds together on the same platform (EMBO2010). Darwin would have saved a lot of his energy, paper and ink had he been provided with a platform like EMBO meetings to convey his ideas and theories among fellow scientists.
Networking is an important issue nowadays among scientists as we are heading towards a border free science. Meetings and conferences have become like the neuronal synapses, without which science would be a little difficult. It helps fellow scientists to know what is going on in other parts of the world and it also provides an insight into the latest developments in research. Conferences and meetings open avenues for inter subject research. With experts of diverse field around there, it provides a chance to know the probabilities of inter subject collaborations.
These conferences are a good platform for young scientists to explore new avenues of research. They help the graduate students and postdocs to look into new avenues for their future.
Scientists need to get out of laboratories, and these scientific conferences and meetings provide them a chance to do so. Apart from the scientific aspect meetings like the EMBO 2010 allow scientists to travel and explore new places.
Fifteen thousand letters, that’s the number of letters which the Darwin Correspondence Project claims to have archived. These are letters which Darwin and his contemporary biologists exchanged. What was the purpose? The answer is NETWORKING. Darwin would have faired well in twittering or facebooking.
Well in the present day world, it has become much more easier for scientists to come and meet at platforms like the EMBO meetings etc. What else do you need when you have Nobel laureates, an author of a best seller, top scientists, editors of high profile journals, top business companies of science and the young minds together on the same platform (EMBO2010). Darwin would have saved a lot of his energy, paper and ink had he been provided with a platform like EMBO meetings to convey his ideas and theories among fellow scientists.
Networking is an important issue nowadays among scientists as we are heading towards a border free science. Meetings and conferences have become like the neuronal synapses, without which science would be a little difficult. It helps fellow scientists to know what is going on in other parts of the world and it also provides an insight into the latest developments in research. Conferences and meetings open avenues for inter subject research. With experts of diverse field around there, it provides a chance to know the probabilities of inter subject collaborations.
These conferences are a good platform for young scientists to explore new avenues of research. They help the graduate students and postdocs to look into new avenues for their future.
Scientists need to get out of laboratories, and these scientific conferences and meetings provide them a chance to do so. Apart from the scientific aspect meetings like the EMBO 2010 allow scientists to travel and explore new places.
Monday, September 6, 2010
EMBO Global Exchange & The Wellcome Trust/ DBT India Alliance Meeting.
What is the purpose of such meetings and conferences ? Do scientists really need to have such meetings ?
Imagine what would happen if the synapses between the neurons were not formed in us. Science in the present day, without networking would be like a nervous system without the ability of form synapses. EMBO aims at bringing scientists from across the globe together so that there is more interaction and people know what is going on in other parts of the world. Dr Venki Ramakrishnan, at the outset of his talk, said that he was attending the meeting because, as a scientist of Indian origin, he wanted to know what was going on in India. It was with this objective of sharing knowledge, that the above meeting was held at the EMBO 2010 , Barcelona meeting.
The meeting started with a welcome address followed by a series of talks which ranged from ribosomes, vaccines, stem cells, policy matters and of course funding issues (after all money makes the world go round). The panel discussion on research opportunities spiced up the meeting, with the conversations between the panelists and the audience (mostly young indian scientists based outside India). Dr Venki gave keynote talk on ribosomes, with an insight into its structure.
Dr Vijayraghavan`s talk on the development of movement was not just focused on the movement in animals, but it also focused on the development of biological science research in India. He gave an overview of the genesis of life science research in modern India, which started sometime in the late 19th and early 20th century. With the establishment of institutions like Bose Institute, Calcutta (now Kolkata), Indian Institute of Science , Bangalore (now Bengaluru), the Bhabha Research Institute in Bombay (now Mumbai), etc, research in the field of life sciences gained momentum. After the independence of India, many centres of excellence came into existence in the form of national research institutes each of which was a feather in the cap of life science research in India. The present government has taken steps to increase the number of centrally aided universities and open new research institutions across the length and breadth of the country to facilitate quality higher education to the masses of India.
The Wellcome Trust/ DBT India Alliance is facilitating quality research opportunities for scientists in India and as Dr Anuradha said, it aimed at bringing people with a taste for quality research into India. The panel discussion which followed the talks of Anuradha and Gerlind, discussed about the opportunities researchers have in India. Embo Director, Maria said that Indians outside India could help India develop by adding their share of knowledge once they are back to their country. In response to a question about the problems one faces in India at different levels, Anuradha, with a very positive approach said that, what people take as problems should be taken up as challenges and dealt with a positive attitude rather than complaining about them. The panelists further added that money for research in India was not a problem, but the real problem was lack of good working hands.
There were eminent scientists of India and also from outside India like Dr Partha Majumder, Rashna Bhandari, Sandhya Visweswariah, Azim Surani, Vivel Malhotra, Ashok Venkitaraman and Satyajit Rath, who spoke on various scientific issues. The meeting ended with a positive note of bringing collaboration and mutual understanding among the scientists of India and the whole world.
Imagine what would happen if the synapses between the neurons were not formed in us. Science in the present day, without networking would be like a nervous system without the ability of form synapses. EMBO aims at bringing scientists from across the globe together so that there is more interaction and people know what is going on in other parts of the world. Dr Venki Ramakrishnan, at the outset of his talk, said that he was attending the meeting because, as a scientist of Indian origin, he wanted to know what was going on in India. It was with this objective of sharing knowledge, that the above meeting was held at the EMBO 2010 , Barcelona meeting.
The meeting started with a welcome address followed by a series of talks which ranged from ribosomes, vaccines, stem cells, policy matters and of course funding issues (after all money makes the world go round). The panel discussion on research opportunities spiced up the meeting, with the conversations between the panelists and the audience (mostly young indian scientists based outside India). Dr Venki gave keynote talk on ribosomes, with an insight into its structure.
Dr Vijayraghavan`s talk on the development of movement was not just focused on the movement in animals, but it also focused on the development of biological science research in India. He gave an overview of the genesis of life science research in modern India, which started sometime in the late 19th and early 20th century. With the establishment of institutions like Bose Institute, Calcutta (now Kolkata), Indian Institute of Science , Bangalore (now Bengaluru), the Bhabha Research Institute in Bombay (now Mumbai), etc, research in the field of life sciences gained momentum. After the independence of India, many centres of excellence came into existence in the form of national research institutes each of which was a feather in the cap of life science research in India. The present government has taken steps to increase the number of centrally aided universities and open new research institutions across the length and breadth of the country to facilitate quality higher education to the masses of India.
The Wellcome Trust/ DBT India Alliance is facilitating quality research opportunities for scientists in India and as Dr Anuradha said, it aimed at bringing people with a taste for quality research into India. The panel discussion which followed the talks of Anuradha and Gerlind, discussed about the opportunities researchers have in India. Embo Director, Maria said that Indians outside India could help India develop by adding their share of knowledge once they are back to their country. In response to a question about the problems one faces in India at different levels, Anuradha, with a very positive approach said that, what people take as problems should be taken up as challenges and dealt with a positive attitude rather than complaining about them. The panelists further added that money for research in India was not a problem, but the real problem was lack of good working hands.
There were eminent scientists of India and also from outside India like Dr Partha Majumder, Rashna Bhandari, Sandhya Visweswariah, Azim Surani, Vivel Malhotra, Ashok Venkitaraman and Satyajit Rath, who spoke on various scientific issues. The meeting ended with a positive note of bringing collaboration and mutual understanding among the scientists of India and the whole world.
EMBO 2010
Networking, Science, Business, Policy making, Career are the ingredients of the EMBO 2010, Barcelona. To add flavour to it there are talks by scientists like Dr Venki, Dr Elizabeth, Dr Frans de Waal and many more...
Sunday, August 22, 2010
Avatars and Evolution...!!!!
The tortoise incarnation of Vishnu.
The ficus wonders if the avataric concept of lord Vishnu in hinduism, is an indication to the knowledge of evolution among the ancient hindus.
As we all know, now, that life originated in water and then it came to land followed by evolution of plants and animals which was again followed by speciation. The avatars of lord Vishnu, as mentioned in the hindu scriptures follow a sequence which supports modern day concept of evolution and origin of life. The first avatar of lord Vishnu is that of a fish (Matsya), followed by tortoise (Kurma), boar (Vraha), half lion- half man (Narsimha), a dwarf man (Vamana) and then different human forms Parushurama, Rama, Krishna, Buddha and Kalki.
What are your views.....
Wednesday, August 11, 2010
Ficus talks about Transgenic (Part 2)
It was Dashahra and Timeline happened to be in the village. Having had a tough time moving here and there around the world, Ficus had forced the Timeline to stay for a couple of months and asked to carry on his business staying there. It was during this time that the trouble of the transgenic crops had come up; and so Ficus engaged Timeline in this discussion.
It was early morning and the birds had come out. the warblers were chattering and the crows had started to crow. The farmers had let open the doors of their chicken coops and the graceful cocks started courting the big fat hens. The milkmen were readying the cows to milk them. The priest was hurrying to the temple with flowers in one hand and a bunch of keys of the temple in other. The palace which sleeps for most of the year was also alive as it was Dashahra. Slowly the whole village was coming to life.
Ficus was telling Timeline about the antiquity of the Dashahra festival and how he had witnessed dashara procession of the royals since the past 100 or so years. As they were talking, Shanker and Shyamu were going to their fields and they were discussing about the Bt Rice they had grown this season. This reminded Ficus of the opposition and pressure from various organisations, which these two progressive farmers were facing. And then he asked Timeline for his view on Transgenic crops. Timeline in his typical husky voice started telling Ficus about such problems which time and again have cropped up and homo sapiens have overcome since the past 200 thousand or so years.
It was early morning and the birds had come out. the warblers were chattering and the crows had started to crow. The farmers had let open the doors of their chicken coops and the graceful cocks started courting the big fat hens. The milkmen were readying the cows to milk them. The priest was hurrying to the temple with flowers in one hand and a bunch of keys of the temple in other. The palace which sleeps for most of the year was also alive as it was Dashahra. Slowly the whole village was coming to life.
Ficus was telling Timeline about the antiquity of the Dashahra festival and how he had witnessed dashara procession of the royals since the past 100 or so years. As they were talking, Shanker and Shyamu were going to their fields and they were discussing about the Bt Rice they had grown this season. This reminded Ficus of the opposition and pressure from various organisations, which these two progressive farmers were facing. And then he asked Timeline for his view on Transgenic crops. Timeline in his typical husky voice started telling Ficus about such problems which time and again have cropped up and homo sapiens have overcome since the past 200 thousand or so years.
Friday, August 6, 2010
Ficus talks about Transgenic (Part 1)
It was a bright sunny day and the farmers were getting ready to harvest the rice. The ficus was busy as guests from Siberia had started to arrive. Timeline was brooding upon the future of humans and that of the earth. The winds were making the rice fields sway and it looked as if a woman clad in a green Saree had let her Saree loose. The palace of the former raja stood prominently besides the big pond where women were bathing and children swimming. Once in a while the bell of the temple built by the former Raja's ancestors would go "DONGGGG...".The ficus was respected equally by the flora and the fauna of the region. the humans respected it because they believed it was a God, the travelers loved it for its shade, the birds loved it because it gave them shelter, the goats and cattle loved it for its shade and leaves, the bats and smaller mammals loved it for its fruits and so on...
There was a problem brewing in the village for the last three to four months. The crops had come to ficus for getting justice. Essentially they were divided into two groups the Transgenic and the non transgenic ones. The non transgenic ones were the orthodox type who were supported by a big NGO and those hideous insects as their witnesses and then there were these transgenic ones who had a scientist Dr Rama as their supporter and two farmers Shanker and Shyamu as their witnesses. Arguments had been going on since the past 3 months and it was the day ficus had summoned all the flora and fauna to let them know of his opinion in consultation with the timeline, his mentor and guru.
The time came and when everyone had assembled, ficus cleared his throat "i have seen this village grow in front of me, i have seen people come and go and in the process the making of this village. there have been umptieth number of cases which have come before me like the issue of the fertilizers, then the tractors, then the hybrids and yet another issue has come up now , now it is the Transgenic issue. I welcome you all and would like to tell my opinion about the fate of the transgenic".
There was a problem brewing in the village for the last three to four months. The crops had come to ficus for getting justice. Essentially they were divided into two groups the Transgenic and the non transgenic ones. The non transgenic ones were the orthodox type who were supported by a big NGO and those hideous insects as their witnesses and then there were these transgenic ones who had a scientist Dr Rama as their supporter and two farmers Shanker and Shyamu as their witnesses. Arguments had been going on since the past 3 months and it was the day ficus had summoned all the flora and fauna to let them know of his opinion in consultation with the timeline, his mentor and guru.
The time came and when everyone had assembled, ficus cleared his throat "i have seen this village grow in front of me, i have seen people come and go and in the process the making of this village. there have been umptieth number of cases which have come before me like the issue of the fertilizers, then the tractors, then the hybrids and yet another issue has come up now , now it is the Transgenic issue. I welcome you all and would like to tell my opinion about the fate of the transgenic".
Thursday, July 22, 2010
Cellular Philosophy
Vaidurya Pratap Sahi: Cells too are designated for their Karmas...!!!
17 January at 06:07
Rammohan Shukla: They form the RAMRAJYA the so called utopian world!
18 January at 08:35
Vaidurya Pratap Sahi: Very true but, In many places , humans are subjected to work based on their birth. But this is against nature. The basic units of life- the cell- has a choice to develop into a tissue which it wants. They form their own niches. Unless societies across the globe start working on the principle followed by cells, ramrajya will be a dream
18 January at 10:59 ·
Rammohan Shukla: Once they are in there niche They can't (very less probability what you say?) change there type. The development happens under strict bylaws (replication fidility). To change them you have to change there (the templates to undergo replication fidility)
No good change can create tumor :)!
Integrity (karma) is a change IN but not change OF! ( Your comments please)
18 January at 11:16
Rammohan Shukla: Integrity (Dharma)
18 January at 11:22
Subramanian Sankranarayanan: actualy each cell is a perfect yogi !!! and once it gets selfish it does not last longer,it takes the entire system away...
18 January at 12:09
Rammohan Shukla: I guess its other way round Sir. each cell is selfish and self organized. If it shows any altruistic behaviour it will be a disaster. Interaction with others are there prescribed duties. The best thing about them is that they know there constitutional position and duties which we human often forget.
Selfishness is a virtue. Altruism is a refuge for selfless
19 January at 08:37
Rajiv Krishna Parvathaneni : i agree....cell has the ability to be whatever it wants but it does the greater good of being whats essential
19 January at 09:45
Vaidurya Pratap Sahi: I give 10 on 10 to ram bhaiya and rajiv
19 January at 09:55
Rammohan Shukla : Not yet over Kaju, we have to think over few more issues
what is the role of genome (the inherited iformation) does that define the dharma (Remember, There is change in but not the change of) of the cell (before its birth) or tradition of the cell (what is tradition ? The templates of replication!). what is the role of membrane which limits the expansion of the cell (Is it analogous to the social and ethological membranes).
19 January at 10:31
Rajiv Krishna Parvathaneni: epigenetics and apoptosis are 2 things which i feel signify dharma and karma...but then again how do cells recognise the cycle of life and death...self perpetuity is deeply igrained in us....even when a plant recognises danger to itself and knows it would not survive...it does the next possible thing....reproduce....where is the concept of moksha in nature???
19 January at 11:01
Vaidurya Pratap Sahi: Rajiv, i think that the genome signifies the dharma(as pointed by ram bhaiya) and epigenetics, apoptosis etc are the karmas. from my point of view, the genome is dharma because in all the cells of an individual the genome remains the same (in a society dharma remains the same);
as in real life, we are defined by our karmas, the karmas of the cell (epigenetics etc ...) leads to its end. By end i dont just mean death, end includes its final place. example it may end up being a neuron, or a cell of epethelial tissue, or it may die or it may become cancerous...etc etc...
19 January at 15:31
Vaidurya Pratap Sahi: Ram bhaiya, i agree with our view point that the Genome may be the dharma. And yes, all these replications, translation, transcription, etc are traditions which the cell follows to maintain its identity. the cells know that they need not loose their identity for the greater cause (the cause of life of the individual). i feel these cellular traditions make the cells ready for their future course of life(their karmas) and on a broader perspective we can say that they help cells to maintain dharma(the genome).
As for your question on the role of membranes: i think it is like the social and ethological membranes, but here (in case of cells) it is necessary; but in social and ethological context i dont think it is always necessary to have membranes.
please comment on Rajivs question where is the concept of moksha in nature???"
19 January at 15:50
Rammohan Shukla : I guess we are going away from the topic. The cell can be compared to society (organization,system) not individual. we have to define the an ideal society not an individual. moksha can be in realization. and realization of moksha is for individual not for the society.
Kaju, search where is Hirarchy in cell?
genome can have many function
including Traditions, History, and common factor of all the cellular component (The identity!)
20 January at 14:22
Rammohan Shukla: There are logical redundancies in nature naovality is created by various modes of regulation of similar logics so the cell may not be an exactly anlogous to society try focusing on types and way of regulation.
20 January at 14:26
Rammohan Shukla :Why you guys have stopped discussing?
Rajeev I guess at organizational level we can compare Apoptosis as an ethical move....
Where Ethics are just like balancing the reaction you add or delete from either side to make it stable!
In one of the "jeff's views” It was mentioned that stepping back is also leadership. Please read it if you find time.
22 January at 09:24
Vaidurya Pratap Sahi: Please define ethics and then I will comment...
22 January at 15:26
Rammohan Shukla: They are the bylaws to judge w/er the action taken is right or wrong. It is something which helps the organization/system to remain in a state of
stability.
we have ethics probably To avoid chaos and bring order. Apoptosis is an
ethical move to bring order. This is the process where in the cell can be considered individual as It undergoes apoptosis to propagate the higher
WHOLE (the body) of which it is a part.
Just think on these questions now.....
Does cell has a goal? Does Society has a goal? If so so what is it?
22 January at 16:25 via Email reply
Vaidurya Pratap Sahi: There is hierarchy amongst cells which depends on the type of tissue it belongs to. And mostly this hierarchy is achieved through time of cell cycle. I will deal with this in detail later. Before that I want to answer your question related to cell and society.
24 January at 22:27
Vaidurya Pratap Sahi: The goals of society have changed time and again. Goals depend mostly on the needs/demands (for example food, defence, propogation, etc) and sometimes even on the desires (expansion of kingdoms, promotion of particular religion, etc) of a particular society. Similarly , cells' goals depend on needs/ requirements of the body. Example, if need be , a cell may differentiate or at same time undergo harakiri ( apoptosis). These goals (both of cell and society) are not dependant on an individual but on the interaction of individuals .
24 January at 22:43
Vaidurya Pratap Sahi: Please upload your comments here...
26 January at 11:02
Rammohan Shukla: The only goal is to SUSTAIN! Sustain the order!
The Society has to sustain Values, tradition, culture.....
Homeostasis "The change in but not change of" is how the cell sustains it self!
traditions are some thing which needs to be passed on from one generation to another. They are like DNA template.
Just observe the unicellular prokaryotes and viruses don't bother to pass on the template as it is to the next generation, they don't have proof reading of the replicated template. but what makes the multicellular organism to cross check its replication several time before passing on the template to the next generation. Is it that it knows that daughter cell is going to be in a society.
Many things to write.....!
26 January at 11:03
Vaidurya Pratap Sahi: your observation is worth appreciation. but i have a doubt.
At times we need mutations for our survival or keep the species. if there is this maintenance of genome all the time how will the organism evolve.... what about the importance of mutations in biology?
27 January at 13:50
Rammohan Shukla: "Change in but not the change of" is key to all your questions kaju. most of
the time we confuse adaptations as evolution. Adaptations are conservative. evolution targets behaviours only!
I strongly believe that mutations are not random it is a programmed
adaptation.
your comments please
27 January at 13:58
Vaidurya Pratap Sahi: "Change in but not the change of"
can you explain this elaborately. i am unable to comprehend it completely.
can you, also, validate your view that "mutations are not random it is a programmed"
27 January at 14:08
Rammohan Shukla :give me some time
27 January at 14:32
Vaidurya Pratap Sahi Cells are sleeping
04 March at 14:25
Rammohan Shukla: you made them sleep
04 March at 14:27
Rammohan Shukla: Our Society " Out with the Old, In with the new"
Cell as Society "On with the Old, In with the new"
What are the difference between societies of a developed nation, developing nation and those of underdeveloped nations?
05 March at 09:28
Vaidurya Pratap Sahi: The banyan tree, which has seen the world for quite a few hundred years, believes that the very existence of mankind would have been in question had humans not learnt to "Out with the Old, In with the new"
this is something which is imprinted in the very human nature. had it not been for this, the humans would not have had civilized. fortunately or unfortunately this is directly proportional to the development of any nation/ society. the more the people follow this , more is the development (look around and see all the developed nations) This brings us back to the crossroads where we have to decide whether we need to follow what has been going on or create a new path/ trend...
05 March at 12:57
Rammohan Shukla: And what does the "time line" says about this?
05 March at 13:27
Vaidurya Pratap Sahi : the timeline agreed to the banyan but it had a tone of meloncholy and doubt. The banyan which was much younger to the timeline asked him "thou are the history, the present and will be the future... tell me o great one what is the cause of this melancholy?" To this the timeline replied " O young one. oh ho ho ho (coughs) Human civilisation , which once i thought was the best thing which was connected to me, is the cause of my melancholy. the humans have not been discreet in their ways of civilisation. I agree to the concept of "Out with the Old, In with the new" but with a little bit of discretion... i agree that there is a need for innovation but not at the cause of bringing harm to the Earth. i have seen in the past couple of centuries changes happening which have brought me to this crossroad"
The conversation went on and in it came the topic of genome to which the timeline said "as per the saying Out with the Old, In with the new, the very epitome of a being - the genome- , also follows this on a long term basis; and this is why there is so much diversity on this planet. But the genome gives time to its new forms to adjust with the environment. similar to the genome if the humans become discreet in their march for development, i will have a longer life...." with these words the timeline went in trance.......
05 March at 13:44
Rammohan Shukla :The Banyan Tree: O great one, I belong to this earth and earthly things have
no permanence. as like others I shed my leaves which are old and wear new in every season. but my new generations which come out of me and stay with me
keeps me in there core and the every subsequent generation follows this tradition of "In with the Old and In with the new". I have a long life span
and I witness many generations of change, those helping me to sustain
through changes are no one but my new generations who have "Value" of my presence. Now I realize that its not me in the core of my young generations
but the Values.
In evolution also we witness many phenomenon of "In with the Old and In with
the new" The best example is the human Brain it self. In fact the primates
have the best evolved neocortex which is new in the periphery and old in the core just like me "the banyan"
10 March at 10:49
17 January at 06:07
Rammohan Shukla: They form the RAMRAJYA the so called utopian world!
18 January at 08:35
Vaidurya Pratap Sahi: Very true but, In many places , humans are subjected to work based on their birth. But this is against nature. The basic units of life- the cell- has a choice to develop into a tissue which it wants. They form their own niches. Unless societies across the globe start working on the principle followed by cells, ramrajya will be a dream
18 January at 10:59 ·
Rammohan Shukla: Once they are in there niche They can't (very less probability what you say?) change there type. The development happens under strict bylaws (replication fidility). To change them you have to change there (the templates to undergo replication fidility)
No good change can create tumor :)!
Integrity (karma) is a change IN but not change OF! ( Your comments please)
18 January at 11:16
Rammohan Shukla: Integrity (Dharma)
18 January at 11:22
Subramanian Sankranarayanan: actualy each cell is a perfect yogi !!! and once it gets selfish it does not last longer,it takes the entire system away...
18 January at 12:09
Rammohan Shukla: I guess its other way round Sir. each cell is selfish and self organized. If it shows any altruistic behaviour it will be a disaster. Interaction with others are there prescribed duties. The best thing about them is that they know there constitutional position and duties which we human often forget.
Selfishness is a virtue. Altruism is a refuge for selfless
19 January at 08:37
Rajiv Krishna Parvathaneni : i agree....cell has the ability to be whatever it wants but it does the greater good of being whats essential
19 January at 09:45
Vaidurya Pratap Sahi: I give 10 on 10 to ram bhaiya and rajiv
19 January at 09:55
Rammohan Shukla : Not yet over Kaju, we have to think over few more issues
what is the role of genome (the inherited iformation) does that define the dharma (Remember, There is change in but not the change of) of the cell (before its birth) or tradition of the cell (what is tradition ? The templates of replication!). what is the role of membrane which limits the expansion of the cell (Is it analogous to the social and ethological membranes).
19 January at 10:31
Rajiv Krishna Parvathaneni: epigenetics and apoptosis are 2 things which i feel signify dharma and karma...but then again how do cells recognise the cycle of life and death...self perpetuity is deeply igrained in us....even when a plant recognises danger to itself and knows it would not survive...it does the next possible thing....reproduce....where is the concept of moksha in nature???
19 January at 11:01
Vaidurya Pratap Sahi: Rajiv, i think that the genome signifies the dharma(as pointed by ram bhaiya) and epigenetics, apoptosis etc are the karmas. from my point of view, the genome is dharma because in all the cells of an individual the genome remains the same (in a society dharma remains the same);
as in real life, we are defined by our karmas, the karmas of the cell (epigenetics etc ...) leads to its end. By end i dont just mean death, end includes its final place. example it may end up being a neuron, or a cell of epethelial tissue, or it may die or it may become cancerous...etc etc...
19 January at 15:31
Vaidurya Pratap Sahi: Ram bhaiya, i agree with our view point that the Genome may be the dharma. And yes, all these replications, translation, transcription, etc are traditions which the cell follows to maintain its identity. the cells know that they need not loose their identity for the greater cause (the cause of life of the individual). i feel these cellular traditions make the cells ready for their future course of life(their karmas) and on a broader perspective we can say that they help cells to maintain dharma(the genome).
As for your question on the role of membranes: i think it is like the social and ethological membranes, but here (in case of cells) it is necessary; but in social and ethological context i dont think it is always necessary to have membranes.
please comment on Rajivs question where is the concept of moksha in nature???"
19 January at 15:50
Rammohan Shukla : I guess we are going away from the topic. The cell can be compared to society (organization,system) not individual. we have to define the an ideal society not an individual. moksha can be in realization. and realization of moksha is for individual not for the society.
Kaju, search where is Hirarchy in cell?
genome can have many function
including Traditions, History, and common factor of all the cellular component (The identity!)
20 January at 14:22
Rammohan Shukla: There are logical redundancies in nature naovality is created by various modes of regulation of similar logics so the cell may not be an exactly anlogous to society try focusing on types and way of regulation.
20 January at 14:26
Rammohan Shukla :Why you guys have stopped discussing?
Rajeev I guess at organizational level we can compare Apoptosis as an ethical move....
Where Ethics are just like balancing the reaction you add or delete from either side to make it stable!
In one of the "jeff's views” It was mentioned that stepping back is also leadership. Please read it if you find time.
22 January at 09:24
Vaidurya Pratap Sahi: Please define ethics and then I will comment...
22 January at 15:26
Rammohan Shukla: They are the bylaws to judge w/er the action taken is right or wrong. It is something which helps the organization/system to remain in a state of
stability.
we have ethics probably To avoid chaos and bring order. Apoptosis is an
ethical move to bring order. This is the process where in the cell can be considered individual as It undergoes apoptosis to propagate the higher
WHOLE (the body) of which it is a part.
Just think on these questions now.....
Does cell has a goal? Does Society has a goal? If so so what is it?
22 January at 16:25 via Email reply
Vaidurya Pratap Sahi: There is hierarchy amongst cells which depends on the type of tissue it belongs to. And mostly this hierarchy is achieved through time of cell cycle. I will deal with this in detail later. Before that I want to answer your question related to cell and society.
24 January at 22:27
Vaidurya Pratap Sahi: The goals of society have changed time and again. Goals depend mostly on the needs/demands (for example food, defence, propogation, etc) and sometimes even on the desires (expansion of kingdoms, promotion of particular religion, etc) of a particular society. Similarly , cells' goals depend on needs/ requirements of the body. Example, if need be , a cell may differentiate or at same time undergo harakiri ( apoptosis). These goals (both of cell and society) are not dependant on an individual but on the interaction of individuals .
24 January at 22:43
Vaidurya Pratap Sahi: Please upload your comments here...
26 January at 11:02
Rammohan Shukla: The only goal is to SUSTAIN! Sustain the order!
The Society has to sustain Values, tradition, culture.....
Homeostasis "The change in but not change of" is how the cell sustains it self!
traditions are some thing which needs to be passed on from one generation to another. They are like DNA template.
Just observe the unicellular prokaryotes and viruses don't bother to pass on the template as it is to the next generation, they don't have proof reading of the replicated template. but what makes the multicellular organism to cross check its replication several time before passing on the template to the next generation. Is it that it knows that daughter cell is going to be in a society.
Many things to write.....!
26 January at 11:03
Vaidurya Pratap Sahi: your observation is worth appreciation. but i have a doubt.
At times we need mutations for our survival or keep the species. if there is this maintenance of genome all the time how will the organism evolve.... what about the importance of mutations in biology?
27 January at 13:50
Rammohan Shukla: "Change in but not the change of" is key to all your questions kaju. most of
the time we confuse adaptations as evolution. Adaptations are conservative. evolution targets behaviours only!
I strongly believe that mutations are not random it is a programmed
adaptation.
your comments please
27 January at 13:58
Vaidurya Pratap Sahi: "Change in but not the change of"
can you explain this elaborately. i am unable to comprehend it completely.
can you, also, validate your view that "mutations are not random it is a programmed"
27 January at 14:08
Rammohan Shukla :give me some time
27 January at 14:32
Vaidurya Pratap Sahi Cells are sleeping
04 March at 14:25
Rammohan Shukla: you made them sleep
04 March at 14:27
Rammohan Shukla: Our Society " Out with the Old, In with the new"
Cell as Society "On with the Old, In with the new"
What are the difference between societies of a developed nation, developing nation and those of underdeveloped nations?
05 March at 09:28
Vaidurya Pratap Sahi: The banyan tree, which has seen the world for quite a few hundred years, believes that the very existence of mankind would have been in question had humans not learnt to "Out with the Old, In with the new"
this is something which is imprinted in the very human nature. had it not been for this, the humans would not have had civilized. fortunately or unfortunately this is directly proportional to the development of any nation/ society. the more the people follow this , more is the development (look around and see all the developed nations) This brings us back to the crossroads where we have to decide whether we need to follow what has been going on or create a new path/ trend...
05 March at 12:57
Rammohan Shukla: And what does the "time line" says about this?
05 March at 13:27
Vaidurya Pratap Sahi : the timeline agreed to the banyan but it had a tone of meloncholy and doubt. The banyan which was much younger to the timeline asked him "thou are the history, the present and will be the future... tell me o great one what is the cause of this melancholy?" To this the timeline replied " O young one. oh ho ho ho (coughs) Human civilisation , which once i thought was the best thing which was connected to me, is the cause of my melancholy. the humans have not been discreet in their ways of civilisation. I agree to the concept of "Out with the Old, In with the new" but with a little bit of discretion... i agree that there is a need for innovation but not at the cause of bringing harm to the Earth. i have seen in the past couple of centuries changes happening which have brought me to this crossroad"
The conversation went on and in it came the topic of genome to which the timeline said "as per the saying Out with the Old, In with the new, the very epitome of a being - the genome- , also follows this on a long term basis; and this is why there is so much diversity on this planet. But the genome gives time to its new forms to adjust with the environment. similar to the genome if the humans become discreet in their march for development, i will have a longer life...." with these words the timeline went in trance.......
05 March at 13:44
Rammohan Shukla :The Banyan Tree: O great one, I belong to this earth and earthly things have
no permanence. as like others I shed my leaves which are old and wear new in every season. but my new generations which come out of me and stay with me
keeps me in there core and the every subsequent generation follows this tradition of "In with the Old and In with the new". I have a long life span
and I witness many generations of change, those helping me to sustain
through changes are no one but my new generations who have "Value" of my presence. Now I realize that its not me in the core of my young generations
but the Values.
In evolution also we witness many phenomenon of "In with the Old and In with
the new" The best example is the human Brain it self. In fact the primates
have the best evolved neocortex which is new in the periphery and old in the core just like me "the banyan"
10 March at 10:49
Tuesday, January 26, 2010
Etymology
English: Banyan
The banyan derives it's name from Portugese "banean".
Banean is derived from "banya" (Gujarati word for the trading class of Hindus). The tree got it's name because the Hindu baniyas were seen sitting under this tree, discussing trade.
Scientific Classification
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Urticales
Family: Moraceae
Genus: Ficus
Species: Benghalensis
The banyan derives it's name from Portugese "banean".
Banean is derived from "banya" (Gujarati word for the trading class of Hindus). The tree got it's name because the Hindu baniyas were seen sitting under this tree, discussing trade.
Scientific Classification
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Urticales
Family: Moraceae
Genus: Ficus
Species: Benghalensis
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